Vascular Endothelial Growth Factor Receptor-1

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

Also Known As:

fms-Like Tyrosine Kinase; Vascular Endothelial Growth Factor Receptor 1; FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Proto-Oncogene Protein flt; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; FLT VEGF Receptor; Proto Oncogene Protein flt; Receptor, FLT VEGF; Tyrosine Kinase, fms-Like; VEGF Receptor flt 1 Protein; VEGFR-1

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        Vascular Endothelial Growth Factor Receptors: 3385
        Vascular Endothelial Growth Factor Receptor-1: 1319
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        Vascular Endothelial Growth Factor Receptors: 3385
        Vascular Endothelial Growth Factor Receptor-1: 1319
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Vascular Endothelial Growth Factor Receptors: 3385
        Vascular Endothelial Growth Factor Receptor-1: 1319
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        Vascular Endothelial Growth Factor Receptors: 3385
        Vascular Endothelial Growth Factor Receptor-1: 1319

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